Poster Presentations: Wednesday, November 3, 2010 |

Effects and Rationale of Micronutrient Supplementation in the Treatment of Smear-Positive Pulmonary Tuberculosis Patients FREE TO VIEW

S M Abdullah Al Mamun, MD
Author and Funding Information

National Institute of Diseases of the Chest & Hospital, Dhaka, Bangladesh

Chest. 2010;138(4_MeetingAbstracts):675A. doi:10.1378/chest.10084
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Published online


PURPOSE: : The ancient killer Tuberculosis is one of the major health problem, caused by Mycobacterium tuberculosis. Globally about 2 billion people are infected , 8 million develop active diseases & 2 million die per year . Though modern treatment cures the patient within 6 months , this long duration of smear& culture conversion favors transmission & acquired drug resistance .Malnutrition a common association with TB puts a patient deficient in various micronutrient like vitamin A & zinc , unique to facilitate the anti TB immunity by influencing CD4 cells & macrophages & by their antioxidant properties.

METHODS: A randomized, controlled, prospective study was carried in the, National institute of diseases of the chest & hospital , Dhaka, Bangladesh. Among 119 smear positive TB patients 111 patients had completed the study . 54 patient(group A) had received vitamin A& zinc supplements ,57(group B) did not .Lab investigation(HB%, ESR , CRP ,CXR) were carried out & clinical evaluation was made in each patients on arrival in the ward .Group A received CAT-1 anti TB +Vit-A(5000 iu/d) & Zinc(15mg/d). GroupB received only CAT-1 antiTB. After completion of intensive phase(2 months) further evaluation was made.

RESULTS: Radiological improvement , rise of HB%, fall of ESR & CRP were more in micronutrients group . Smear conversion( more in groupA) had statistically significant difference between two groups of patients (p<0.001.

CONCLUSION: Vitamin A & zinc supplementation in intensive phase reveals better result than no supplement.

CLINICAL IMPLICATIONS: Vitamin A & zinc supplementation in intensive phase may benificial for early sputum conversion & patient may go back to work earlier.

DISCLOSURE: S M Abdullah Al Mamun, No Financial Disclosure Information; No Product/Research Disclosure Information

12:45 PM - 2:00 PM




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