PURPOSE: : The ancient killer Tuberculosis is one of the major health problem, caused by Mycobacterium tuberculosis. Globally about 2 billion people are infected , 8 million develop active diseases & 2 million die per year . Though modern treatment cures the patient within 6 months , this long duration of smear& culture conversion favors transmission & acquired drug resistance .Malnutrition a common association with TB puts a patient deficient in various micronutrient like vitamin A & zinc , unique to facilitate the anti TB immunity by influencing CD4 cells & macrophages & by their antioxidant properties.
METHODS: A randomized, controlled, prospective study was carried in the, National institute of diseases of the chest & hospital , Dhaka, Bangladesh. Among 119 smear positive TB patients 111 patients had completed the study . 54 patient(group A) had received vitamin A& zinc supplements ,57(group B) did not .Lab investigation(HB%, ESR , CRP ,CXR) were carried out & clinical evaluation was made in each patients on arrival in the ward .Group A received CAT-1 anti TB +Vit-A(5000 iu/d) & Zinc(15mg/d). GroupB received only CAT-1 antiTB. After completion of intensive phase(2 months) further evaluation was made.
RESULTS: Radiological improvement , rise of HB%, fall of ESR & CRP were more in micronutrients group . Smear conversion( more in groupA) had statistically significant difference between two groups of patients (p<0.001.
CONCLUSION: Vitamin A & zinc supplementation in intensive phase reveals better result than no supplement.
CLINICAL IMPLICATIONS: Vitamin A & zinc supplementation in intensive phase may benificial for early sputum conversion & patient may go back to work earlier.
DISCLOSURE: S M Abdullah Al Mamun, No Financial Disclosure Information; No Product/Research Disclosure Information