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Poster Presentations: Wednesday, November 3, 2010 |

The Prevalence of Airway Obstruction in Subjects With a History of Pulmonary Tuberculosis in Mexico FREE TO VIEW

Rafael Laniado-Laborin, MPH; Adrián Rendón; Otto Bauerle
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Universidad Autónoma de Baja California, Tijuana, Mexico



Chest. 2010;138(4_MeetingAbstracts):449A. doi:10.1378/chest.10083
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Abstract

PURPOSE: Pulmonary tuberculosis (PTB) and Chronic Obstructive Pulmonary Disease (COPD) carry a significant burden in terms of morbidity and mortality worldwide, especially in developing countries. In the PLATINO study the overall prevalence of airflow obstruction (AO) in Mexico City defined as VEF-1% < 70 was 30.7% among those with a history of tuberculosis, compared with 13.9% among those without it. Our objective was to investigate the association between spirometric AO and a history of PTB in Mexico.

METHODS: Individuals 40 years or older with known risk factors for COPD (smoking or exposure to biomass smoke) whether symptomatic or not, were referred by first-contact physicians. After obtaining written informed consent they were invited to answer a questionnaire and undergo pre and postbronchodilator spirometry. We defined AO as a postbronchodilator (PB) FEV1/FVC< 0.7.

RESULTS: Among 2,284 subjects from 27 Mexican cities, 26 had a clinical history of PTB (1.13%) diagnosed 22.8 (SD 15.7) years before; the rate among those with AO was 2.6% vs. 0.8% for those without AO (p=0.003, OR 3.39, 95%CI: 1.54, 7.3). The overall prevalence of airway obstruction in subjects with a history of tuberculosis was 46.2% vs. 20.3% among those without that history (p< 0.01). The degree of airway obstruction was similar for subjects with a history of PTB (PB FEV1/FVC=54.7%) and those without it (58.1%, p=0.26).

CONCLUSION: The history of previous PTB was associated with a higher prevalence of airway obstruction linking two of the most common diseases in the country.

CLINICAL IMPLICATIONS: The prevention through latent tuberculosis infection treatment and an earlier diagnosis and adequate treatment of active tuberculosis might reduce the burden of airflow obstruction in Mexico.

DISCLOSURE: Rafael Laniado-Laborin, University grant monies I have received grant monies from the University of California San Diego for a multidrug resistant tuberculosis study primarily funded by The National Institute of Allergy and Infectious Diseases (NIAID) from the National Institute of Health (NIH); Grant monies (from industry related sources) I have recieved grant monies from GSK México and Schering-Plough (now Merk) for COPD clinical research. I will NOT be discussing information about any diagnostic or therapeutic product/procedure/technique either already approved for its use or that is considered research and is NOT yet approved for any purpose.; Consultant fee, speaker bureau, advisory committee, etc. During the last 12 months I have received fees from Glaxo-Smith-Kline to participate on an advisory committee for COPD related products. My current presentation includes only epidemiological information on the prevalence of disease in Mexico. I will NOT be discussing information about any diagnostic or therapeutic product/procedure/technique either already approved for its use or that is considered research and is NOT yet approved for any purpose.; Other No conflict of interest since my presentations are about epidemiological data and I will NOT be discussing information about any diagnostic or therapeutic product/procedure/technique either already approved for its use or that is considered research and is NOT yet approved for any purpose.; No Product/Research Disclosure Information

12:45 PM - 2:00 PM


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