Poster Presentations: Wednesday, November 3, 2010 |

The Effect of Antioxidant Intake on Pulmonary Function in Chronic Lung Disease Is Moderated by Gender FREE TO VIEW

Mohammad S. Khan, DO; Rachel Pohle-Krauza, PhD; Michele McCarroll, PhD; Matthew L. Krauza, MD
Author and Funding Information

Summa Health System, Akron City Hospital, Akron, OH

Chest. 2010;138(4_MeetingAbstracts):488A. doi:10.1378/chest.10055
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PURPOSE: The objective of this study was to assess habitual dietary intake of antioxidants in a sample of patients with Chronic Obstructive Pulmonary Disease (COPD). A secondary aim was to examine the relationship between these dietary variables and pulmonary function as measured by Forced Vital Capacity (FVC).

METHODS: Twenty participants (13 female, 7 male) completed a take-home, self-administered, food frequency questionnaire (FFQ) in order to assess habitual dietary intake of Vitamins A, C, D, E and Selenium (i.e. usual intakes within the past 12 months). Nutrient data were compared to nationally-recognized guidelines (Dietary Reference Intakes [DRIs]). Participants also underwent assessment of pulmonary function. Data were analyzed using SAS 9.1. Descriptive statistics were used to show the mean and range for micronutrient intakes, and frequencies were used to compare nutrient intakes of participants to previously-established normative values. The general linear model was used to test for effects of nutrient intake as a categorical covariate (i.e. over or under the DRI value for each nutrient; Deficient, DE or Not Deficient, NDE), gender (male or female) and all interactions of these variables, with a primary endpoint of FVC.

RESULTS: Results of the analysis showed 25%, 45%, 90%, 55%, and 70% of participants had deficient intakes of Selenium, Vitamin C, Vitamin E, Vitamin A and Vitamin D respectively. Main effects of deficiency status were found for Selenium where FVC was decreased in those participants who were DE (compared to NDE). Two-way interactions of deficiency status and gender were found for Vitamins A, C, and D, where FVC was lower in the DE compared to NDE groups in male, but not female, participants.

CONCLUSION: The contribution of antioxidant deficiency to decreased lung function in COPD patients appears to be more pronounced in men compared to women. Further studies examining the effect of antioxidant intake and gender on lung function in COPD are warranted.

CLINICAL IMPLICATIONS: Strategies for dietary modification and supplementation should be considered in patients with COPD.

DISCLOSURE: Mohammad Khan, No Financial Disclosure Information; No Product/Research Disclosure Information

12:45 PM - 2:00 PM




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