PURPOSE: The aim of this analysis was to report the spirometric reference values for 5 sites in Canada based on the data collected in the population-based Canadian Obstructive Lung disease [COLD] study.
METHODS: From 3042 subjects in the population-based COLD study with spirometric measurements before and after bronchodilator admministration, in Vancouver, Montreal, Toronto, Halifax, Calgary, we identified 1214 [998 (82% ) Caucasians] nonsmoking healthy, asymptomatic individuals aged 40 years and older to provide normative reference values for spirometry. These people had never smoked and had not been diagnosed with respiratory diseases . Multiple regression models were constructed separately for Caucasian men and women for the following spirometric parameters : forced expiratory volume in 1 second [FEV1], forced vital capacity [FVC], FEV1/FVC with covariates of height, sex and age.
RESULTS: Comparison with published regression equations showed that the best fit was obtained if the reference population was population-based and the age range was similar.
CONCLUSION: The proposed reference values add to what is currently available for Canada as the subjects were chosen by random population-based method and lung function measurements were stringently monitored.
CLINICAL IMPLICATIONS: These are the first reference or normative values for spirometry in healthy asymptomatic subjects from the Canadian population.
DISCLOSURE: Wan Tan, No Financial Disclosure Information; No Product/Research Disclosure Information