Slide Presentations: Tuesday, November 2, 2010 |

Spirometric References Values in Five Canadian Cities for Subjects 40 Years and Older: Results From the Canadian Obstructive Lung Disease (COLD) Study FREE TO VIEW

Wan C. Tan, MD; Daniel Chen; Jean Bourbeau, MD; Robert Cowie, MD; Kenneth Chapman, MD; Paul Hernandez, MD; Mark FitzGerald, MD; Don Sin, MD
Author and Funding Information

University of British Columbia iCapture center, St Paul’ s hospital, Vancouver, BC, Canada

Chest. 2010;138(4_MeetingAbstracts):813A. doi:10.1378/chest.10031
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PURPOSE: The aim of this analysis was to report the spirometric reference values for 5 sites in Canada based on the data collected in the population-based Canadian Obstructive Lung disease [COLD] study.

METHODS: From 3042 subjects in the population-based COLD study with spirometric measurements before and after bronchodilator admministration, in Vancouver, Montreal, Toronto, Halifax, Calgary, we identified 1214 [998 (82% ) Caucasians] nonsmoking healthy, asymptomatic individuals aged 40 years and older to provide normative reference values for spirometry. These people had never smoked and had not been diagnosed with respiratory diseases . Multiple regression models were constructed separately for Caucasian men and women for the following spirometric parameters : forced expiratory volume in 1 second [FEV1], forced vital capacity [FVC], FEV1/FVC with covariates of height, sex and age.

RESULTS: Comparison with published regression equations showed that the best fit was obtained if the reference population was population-based and the age range was similar.

CONCLUSION: The proposed reference values add to what is currently available for Canada as the subjects were chosen by random population-based method and lung function measurements were stringently monitored.

CLINICAL IMPLICATIONS: These are the first reference or normative values for spirometry in healthy asymptomatic subjects from the Canadian population.

DISCLOSURE: Wan Tan, No Financial Disclosure Information; No Product/Research Disclosure Information

08:00 AM - 09:15 AM




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