PURPOSE: Recent epidemiological investigations have reported a relationship between asthma and cardiovascular disease (CVD). While asthma is known to be associated with CVD, the relation to individual manifestations of CVD, such as myocardial infarction, stroke, heart failure or angina, has not been previously well described. We explored the relation of asthma with specific CVD components.
METHODS: We included 16,943 adults (52% female) age 20 or older from the National Health and Nutrition Examination Survey 2000-2006 with information on asthma. Adult-onset asthma was defined as having been diagnosed with asthma when aged 20 or older. The prevalent CVD conditions studied were myocardial infarction, angina, stroke, congestive heart failure, coronary heart disease and total CVD. Logistic regression was done to determine the odds ratio of each condition based on asthma status. Estimates were adjusted for body mass index, C-reactive protein, diabetes, smoking, total and high density lipoprotein-cholesterol and systolic blood pressure.
RESULTS: 16943 (52% female) adults were studied; the prevalence of adult-onset asthma was 3.3% (n=534) and the prevalence of child-onset asthma was 4.8% (n=702). 13.8% (n=95) of the adult-onset population and 5.3% (n=44) of the child-onset group had prevalent CVD. Of the six CVD conditions, adult-onset asthma was significantly associated only with angina (OR: 2.94 CI: 1.26 - 6.91), coronary heart disease (CHD) (OR: 2.26 CI: 1.23 - 4.17) and total CVD (OR: 2.07 CI: 1.17 - 3.66). Child-onset asthma was found to have no association to any of the CVD conditions.
CONCLUSION: Only individuals with adult-onset asthma had an increased likelihood for CVD, CHD, and angina when compared to non-asthmatics. This suggests that angina and CHD overall are the most important manifestations of CVD related to adult-onset asthma.
CLINICAL IMPLICATIONS: This finding may help to best focus CVD prevention efforts in adult- onset asthmatic patients around angina and CHD.
DISCLOSURE: Hwa Lee, No Financial Disclosure Information; No Product/Research Disclosure Information