PURPOSE: We describe clinical presentation of H1N1 cases attending Taiyuan fourth people hospital, Shanxi, between September through December 2009.
METHODS: The 99 H1N1 patients who were clinically diagnosed and confirmed positive for novel influenza A (H1N1) using reverse transcription polymerase chain reaction (RT-PCR) were included in the study. The routine laboratory test data were collected and analyzed. CT images were used to indicate the lung injury.
RESULTS: In 99 confirmed cases, the most commonly reported symptoms were fever in 99 (100%), cough in 77 (77.8%), sputum in 60(60.6%), sore throat in 40 (40.4%) and runny nose in 20 (20.2%). All 99 cases were confirmed positive using real time RT-PCR testing. 50 cases (50.5%) had pulmonary complications such as acute pneumonia and interstitial pneumonia. 20 cases (20.2%) suffered from other organ complications 9 cases (14.1%) with cardiac disease; 7 cases (8.5 %) with renal disease; 18 cases (22.9%) with liver diseases, 20 cases (54.1%) with impairment of immunological system). These patients completely recovered after receiving oseltamivit and the intensitive care unit (ICU) management. The CT images showed that some of cases with influenza A H1N1 infection suffered from both acute pneumonia and interstitial pneumonia at the same time. There were some patients with pleural lesions. On the 40th day after the incidence, some of patients had pulmonary fibrosis, which remained when these patients discharged from the hospital.
CONCLUSION: Lung lesions were major complications of H1N1 patients. Aggressive ICU management and experience in effective oxygen therapy significantly improved outcomes. Early antiviral treatment may have played an important role in the severe cases.
CLINICAL IMPLICATIONS: Oseltamivir effectively treated the H1N1 patients. The effective oxygen therapy and respiratory support were the basis for treatment. The damages of heart, liver, kidney and blood system gradually returned to normal with the improvement of the patient conditions. In some patients, lung lesions were completely absorbed, but there were still some patients left lung fibrosis.
DISCLOSURE: Hong Luo, No Financial Disclosure Information; No Product/Research Disclosure Information