Poster Presentations: Tuesday, November 2, 2010 |

To Compare the Clinical Efficacy and Safety of Salbutamol and Levosalbutamol Metered-Dose Inhalers in Patients of Bronchial Asthma FREE TO VIEW

Hitender Kumar, MBBS; Ashok Goel, MD; Nirmal Chand, MD; Bharat Bhushan, MD; Ramesh Chander, MD; Akshat Goel
Author and Funding Information

Government Medical College, Amritsar, India

Chest. 2010;138(4_MeetingAbstracts):160A. doi:10.1378/chest.9952
Text Size: A A A
Published online


PURPOSE: Salbutamol is the most common β2-agonist being currently used in the treatment of asthma. It was only available as a racemate, a 50:50 mixture of the dextro [(S)-salbutamol] and levo [(R)-salbutamol] rotatory forms. Regular and excessive use of racemate can induce paradoxical reactions in some subjects with asthma. The present study, compared MDI Salbutamol with levo [(R)-salbutamol] isomer over 8 weeks in terms of clinical efficacy and safety.

METHODS: A prospective, parallel design, comparative, intention to treat study lasting eight weeks, involving 80 patient of either sex after taking their informed consent. Patients were randomly divided into 2 groups, A and B of 40 patients each. Patients in Group A and Group B were administered Salbutamol MDI two puffs 100 mcg per puff four times daily and Levosalbutamol MDI two puffs each containing 50 mcg four times daily respectively. Rescue dose two or more puffs was allowed as required and the number of additional doses were counted by patients. Observations were made and analyzed at 0, 4 and 8 weeks for FEV1, FVC, and PEFR and side effects.

RESULTS: Highly significant (p < 0.001) mean percent change in FEV1, FVC and PEFR at 4 and 8 weeks of Group B (Levosalbutamol) patients as compared to mean percent change in FEV1 of Group A (Salbutamol) patients at 4 weeks and 8 weeks.

CONCLUSION: High therapeutic efficacy was observed with the use of the Levosalbutamol MDI with lesser side effects.

CLINICAL IMPLICATIONS: Levosalbutamol can be preferred over salbutamol for better control of asthma symptoms.

DISCLOSURE: Hitender Kumar, No Financial Disclosure Information; No Product/Research Disclosure Information

12:45 PM - 2:00 PM




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
Asthma in pregnancy.
American College of Obstetricians and Gynecologists | 9/19/2008
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543