Poster Presentations: Wednesday, November 3, 2010 |

The Long-term Effect of Suplatast Tosilate in the Patients With Pulmonary Fibrosis FREE TO VIEW

Yuji Saito
Author and Funding Information

Div. of Respiratory Medicine, Fujita Health University, Toyoake, Japan

Chest. 2010;138(4_MeetingAbstracts):535A. doi:10.1378/chest.9927
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PURPOSE: We have reported the short time effect of suplatast tosilate in the patients with pulmonary fibrosis. We have also reported that suplatast tosilate was improved lung functions by decreasing circulating Th1/Th2 lymphocyte balance in the patients with pulmonary fibrosis after 3 months.Then, we investigated the long term effect of suplatast tosilate in the patients with pulmonary fibrosis.

METHODS: Forty-six patients with chronic interstitial pneumonia ( 36 men and 10 women, mean age is 67.3 years old. 36 of IPF and 10 of non-IPF)were studied. Each patient took oral 300mg of suplatast tosilate every day from 1 to 72 months. The serum KL-6 and various lung functions were measured every 6 months.

RESULTS: Our results show that 16 of 46 patients were improved, 21 of 46 patients were stable and 9 of 46 patients were worsened in the lung functions. 4 of 46 patients were died for respiratory failure and 4 of 46 patients were showed acute exacerbation of pulmonary fibrosis. There is no different of the effect of suplatast tosilate between patients with IPF and non-IPF. Patients who stopped taking suplatast tosilate were gotten worse in the pulmonary functions compared with time when suplatast tosilate was taken.

CONCLUSION: Our results indicate that suplatast tosilate has at least stabilized effect of pulmonary functions in patients with pulmonary fibrosis.

CLINICAL IMPLICATIONS: Suplatast tosilate is a potential drug of treatment for idiopathic pulmonary fibrosis.

DISCLOSURE: Yuji Saito, No Financial Disclosure Information; No Product/Research Disclosure Information

12:45 PM - 2:00 PM




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