Slide Presentations: Wednesday, November 3, 2010 |

Airway Dimensions on Computed Tomography in Asthma: Correlation With Airflow Limitation FREE TO VIEW

Makoto Hoshino, MD
Author and Funding Information

Atami Hospital, International University of Health and Welfare, Atami, Japan

Chest. 2010;138(4_MeetingAbstracts):877A. doi:10.1378/chest.9812
Text Size: A A A
Published online


PURPOSE: Asthma is characterized by variable airflow obstruction and airway remodeling. Multidetector CT (MDCT) is useful for the evaluation of airway wall structural changes in asthma. The objective of the study is to assess the relationship between airflow limitation and airway dimensions from the third to fifth generation bronchi in asthma using MDCT.

METHODS: Thirty-eight subjects with asthma were performed spirometry, airway hyperresponsiveness, and underwent MDCT to measure the airway wall area (WA) and luminal area (Ai), WA and Ai corrected by body surface area (BSA), from up to the fifth generation of the apical bronchus (B1) and the posterior basal bronchus (B10).

RESULTS: WA/BSA, WA percentage (WA%) and Ai/BSA in the fifth generation were significantly correlated with forced expiratory volume in 1 s (FEV1)% predicted. The correlation coefficients between WA% and FEV1% predicted improved when tracking the airways from the third to the fifth generation (r = -0.25, r = -0.40, r = -0.63 for B1; r = -0.23, r = -0.47, r = -0.69 for B10). At the generation 5, WA% was greater and Ai/BSA was smaller in severe asthma than mild-to-moderate asthma.

CONCLUSION: These results suggest that airway flow limitation in asthma is closely related to the more distal airways.

CLINICAL IMPLICATIONS: The quantitative analysis of airway dimensions using MDCT could evaluate distal airway remodeling.

DISCLOSURE: Makoto Hoshino, No Financial Disclosure Information; No Product/Research Disclosure Information

08:00 AM - 09:15 AM




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543