0
Poster Presentations: Wednesday, November 3, 2010 |

Clinical Importance of the Oral Secretions in Ventilator-Associated Pneumonia FREE TO VIEW

Han-Chen Tsai, MSN; Fang-Chi Lin, PhD; Yi-Chu Chen, MS; Shi-Chuan Chang, PhD
Author and Funding Information

Taipei Veterans General Hospital, Taipei, Taiwan ROC



Chest. 2010;138(4_MeetingAbstracts):521A. doi:10.1378/chest.9799
Text Size: A A A
Published online

Abstract

PURPOSE: Our previous study indicated that intermittent suction of oral secretions before each positional change could reduce ventilator-associated pneumonia (VAP) occurrence in intensive care unit (ICU) patients. In this study, we liked to explore the clinical importance of inflammatory cytokines, inflammatory biomarkers and total bile acid (TBA) in oral secretions in VAP occurrence of ICU patients.

METHODS: The study consisted of 39 with and 39 without VAP, and 37 nursing staff at ICU. The levels of interleukin(IL)-1β, IL-6, IL-8, tumor necrosis factor-α, soluble intercellular adhesion molecule-1, monocyte chemoattractant-1, C reactive protein, surfactant protein D and TBA in oral secretions were by measured by enzyme-linked immunosorbent assay or spectrophosphometric enzymatic assay.

RESULTS: The levels of inflammatory cytokines and inflammatory biomarkers in oral secretions showed no significant difference between the patients with and without VAP. Significantly higher levels of TBA in oral secretions were found in the patients with VAP than in those without VAP (44.1 ± 97.2μ mol/L vs. 8.6 ± 22.4 μ mol/L, p = 0.003). Compared with nursing staff, the patients with and without VAP had significantly higher levels of inflammatory cytokines, inflammatory biomarkers and TBA in oral secretions.

CONCLUSION: The patients with and without VAP had significantly higher levels of inflammatory cytokines, inflammatory biomarkers and TBA in oral secretions. The levels of TBA in oral secretions were significantly higher in the patients with VAP than those without VAP. TBA in oral secretions may be a useful marker to predict the occurrence of VAP in ICU patients.

CLINICAL IMPLICATIONS: Duodenogastroesophageal reflux may play an important role in the development of VAP in ICU patients and TBA in oral secretion may be a useful marker to predict the occurrence of VAP in such patients.

DISCLOSURE: Han-chen Tsai, No Financial Disclosure Information; No Product/Research Disclosure Information

12:45 PM - 2:00 PM


Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543