PURPOSE: Differences between presentations and outcomes in African Americans(AA) and Whites(W) and between Males(M) and Females(F) are not well established.
METHODS: Methods: The surveillance, Epidemiology, and End results (SEER) was analyzed to identify Cases of (SCLC) between 1973 and 2005. Primary outcome was cancer specific survival(CSS) in AA versus W and in M versus F. Secondary outcomes included incidence and age at presentation.
RESULTS: A total of 94,148 cases of SCLC were identified in the SEER database between 1973-2005. There were 83,280 W and 7,274 AA patients. There was no significant difference in stage of presentation between both groups. AA tend to present at significantly younger age than W. The overall incidence of SCLC is steadily decreasing since 1973. However, SCLC was significantly less in AA, compared to W (14.5% vs 10.5%, P <0.0001. There was a significant and steady increase in the percentage of F since 1973 (M:F ratio is continuously decreasing from 2.6 in 1973 to 0.9 in 2005). This applies to AA and W patients. The two-year and five-year CSS was similar in both AA and white. The CSS rates were significantly higher in F versus M (two-year survival was 17% vs 11.9 %, respectively).
CONCLUSION: The outcome of SCLC was similar AA and W despite presentation at significantly younger ages in AA. Of all bronchogenic cancer cases, the incidence of SCLC is significantly lower in AA compared to W. The incidence of SCLC is also increasing in F compared to M and survival rates are significantly better in F, a finding that indicates possibly a hormonal role in SCLC.
CLINICAL IMPLICATIONS: AA present at a younger age than W in SCLC.F have a better survival than M indicating a hormonal role.Incidence of SCLC is more in W compared to AA.Incidence of SCLC is increasing in F.
DISCLOSURE: Shagun Arora, No Financial Disclosure Information; No Product/Research Disclosure Information