PURPOSE: Back ground: Proton Pump Inhibitors are used for the treatment and prophylaxis of variety of acid peptic conditions. There is a growing body of evidence regarding safety profile and side effects of these medications. Purpose of our study was to measure the inappropriate use of IV Proton Pump Inhibitors for stress ulcer prophylaxis in patients admitted to hospital (floor and ICU) and to estimate the financial burden.
METHODS: Methods: We carried out a retrospective, analytic study from July 2007 to June 2008 in internal medicine department. Medical records of 1104 patients admitted to the hospital during this period were reviewed. All patients received IV Esomeprazole Magnesium during their stay in hospital. About 31.5% of these patients were either admitted directly to ICU or were transferred to critical care during their hospital course.
RESULTS: Results: IV PPI was prescribed for 83.3% of patients without any proper indication. A careful reviewed of data showed that total of 4140 non-indicated injections were given. Estimated Cost = 31050 USD (calculated on the basis of price provided by the pharmacy of hosptal).
CONCLUSION: A more rational use of PPI will have better impact on health care cost and patient safety.
CLINICAL IMPLICATIONS: Proton pump inhibitors are very effective agents for stress ulcer prophylaxis. Recent literature has attributed a growing number of side effects to these drugs. Most widely accepted are an increased incidence of ventilator associated pneumonia, clostridium defficile infection, increased risk of fall in elderly and many serious drug interactions. A more rationale and judicious use will not only prevent unnecessary health care expenditure but will definitely have a positive outcome on patient safety. 3.
DISCLOSURE: Muhammad Perwaiz, No Financial Disclosure Information; No Product/Research Disclosure Information