0
Poster Presentations: Tuesday, November 2, 2010 |

Zinc in Treatment of Acute Lower Respiratory Tract Infection in Children: Pooled Result From Randomized Controlled Trials FREE TO VIEW

Rashmi R. Das, MD; Meenu Singh, MD; Nusrat Shafiq, DM
Author and Funding Information

All India Institute of Medical Sciences (AIIMS), New Delhi, India



Chest. 2010;138(4_MeetingAbstracts):317A. doi:10.1378/chest.9438
Text Size: A A A
Published online

Abstract

PURPOSE: A recent meta-analysis done on preventive role of zinc in childhood respiratory illness found significant reduction in the frequency and severity of respiratory illnesses. We conducted a systematic review on role of zinc as an adjunctive in treatment of acute lower respiratory tract illness (ALRTI) in children.

METHODS: A systematic search of published literature was done. Two reviewers independently applied eligibility criteria and assessed the studies for methodological quality using a standardized data extraction form. Randomized Controlled Trials (RCTs) (Quality score ≥ 3) using zinc as adjunctive in treatment of ALRTI were included. A pre-defined set of outcome measures were assessed. Weighted mean difference (WMD) with 95% confidence interval (CI) was calculated using RevMan (version 4.2.10).

RESULTS: After screening, 4 RCTs (India = 2, Bangladesh = 1, Australia = 1) spanning over 6 years including 909 subjects qualified for inclusion. There was no significant difference between the intervention and placebo group in the time of resolution of severe pneumonia [WMD 4.24 (95% CI -10.26, 18.74; p = 0.57)], as well as duration of hospitalization [WMD -5.07 (95% CI -12.34, 2.21; p = 0.17)]. No significant differences between two groups were noted for, duration of resolution of tachypnea [WMD 1.29 (95% CI -7.49, 10.06; p = 0.77)]; chest indrawing [WMD -3.52 (95% CI -11.59, 4.55; p = 0.39)] and hypoxia [WMD 0.43 (95% CI -8.99, 9.84; p = 0.93)]. However, the serum zinc level showed significant change, with higher level attended after treatment in the intervention group [WMD 2.57 (95% CI 2.1, 3.04; p < 0.00001)]. Side-effects (vomiting, bulging fontanelle) were not significant.

CONCLUSION: The evidence on use of zinc in treatment of ALRTI in children is limited.

CLINICAL IMPLICATIONS: Currently zinc can not be recommended as an adjunctive in treatment of ALRTI in children. Large multicentre RCTs in both developing and developed countries are needed before any firm conclusion can be made.

DISCLOSURE: Rashmi Das, No Financial Disclosure Information; No Product/Research Disclosure Information

12:45 PM - 2:00 PM


Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543