PURPOSE: The best prognosis for lung cancer can be expected by diagnosis at an early stage of the disease. Although autofluorescence bronchoscopy is the best ways to screen central airway lesion in the a high risk group, those are not popular because of invasive and expensive procedures. It is necessary to introduce less invasive and cheaper procedure for the early detection of central lung cancer. most simply considerable method is sputum cytology because of non-invasive and cheap. But, the use of conventional sputum cytology for the early detection of central lung cancer is not supported by the published evidence. Recently, sputum cytology using Thinprep® was reported that it improved the diagnostic accuracy for evaluating lung cancer by reducing the unsatisfactory and false-negative rates. So, we evaluated that how much sptum cytology using Thinprep® is useful compare to autofluorescence bronchoscopy .
METHODS: In this study ,41 participants( adults> 50 years old who had smoked at least 30 pack-years or lung cancer family history) underwent prevalence screening with LDCT, autofluorescence bronchoscopy and Thinprep® from february 2009 through october 2009.and then, we compared autofluorescence’s result to Thinprep®’’s.
RESULTS: The mean age of the patients was 63.027.5 years. Smoking history were current smoker 29, ex-smoker 11, non-smoker 1 . lung cancer family history 4. During the baseline screening 4 squamous metaplasia case ,1 stage 0 case were detected by autofluorescence bronchoscopy. but sputum cytology using Thinprep® was negatively resulted.
CONCLUSION: This study suggested that sputum cytology using Thinprep® in not useful compare to autofluorescence bronchoscopy for evaluation of metaplasia in a high risk group(P=0.04).But, to evaluate the usefulness in detection of central early lung cancer in a high risk group, more data collection is needed.
CLINICAL IMPLICATIONS: For detection of early lung cancer, LDCT and autofluorescence bronchoscopy will be needed.
DISCLOSURE: Eun Lee, No Financial Disclosure Information; No Product/Research Disclosure Information