PURPOSE: Obstructive sleep apnea syndrome (OSAS) is associated cardiovascular abnormalities including left ventricular dysfunction. N-terminal fraction of brain natriuretic peptide (NT-proBNP) is a hormone which may reflect the severity of underlying cardiac dysfunction and be elevated levels have been associated with diminished left ventricular functional capacity. The aim of present study is evaluate whether NT-proBNP is related to OSAS and the effect of continuous positive airway pressure (CPAP) therapy.
METHODS: Thirty seven patients who were referred to our sleep disorders center with a suspicion of OSAS were consecutively included in the study. Exclusion criteria included cardiovascular diseases. The subjects were examined with polysomnography (PSG) and classified as controls according to data of the apnea-hypopnea index (AHI< 5). All patients with OSAS were also diagnosed with PSG (AHI≥5). All cases underwent NT-proBNP measurement.
RESULTS: Serum NT-proBNP levels were significantly higher in OSAS group (n=20) than control group (n=17) (p=0.03). We showed that in OSAS patients serum NT-proBNP levels were decreased after 4 weeks of CPAP treatment (p=0.005).
CONCLUSION: NT-proBNP levels reflect underlying cardiac dysfunction associated with OSAS.
CLINICAL IMPLICATIONS: Yes.
DISCLOSURE: Oguz Kokturk, No Financial Disclosure Information; No Product/Research Disclosure Information