PURPOSE: B-type naturiuretic peptide (BNP) and ejection fraction (EF) are the marker of the hear failure. We investigated the shift of the BNP and EF after coronary artery bypass grafting in the patients with ischemic cardiomyopathy.
METHODS: Consecutive cases of coronary artery bypass grafting performed between 2002 and 2007 were placed into the systematic database. 50 patients (42 male and 8 female, mean age of 64± 9, group S) whose preoperative ejection fraction (EF) was less than 30%, and 85 patients (73 male and 12 female, mean age of 65± 10, group M) whose preoperative ejection fraction (EF) was between 30 and 40%, were identified. BNP were obtained before surgery, before discharge hospital and first postoperative clinic visit. The EF was determined by echocardiography at the same time of BNP drawn.
RESULTS: In group S, EF was improved from 22 ± 4% before surgery to 32 ± 13% at discharge and 33 ± 13% at clinic visit (p< 0.001 between before surgery and at discharge). In group M, EF was not significantly changed from 36 ± 5% before surgery to 36 ± 13% at discharge and 38 ± 12% at clinic visit. Similarly, BNP was improved in group S from 1118 ± 1789 pg/ml before surgery to 636 ± 772 pg/ml and 331 ± 843 pg/ml (p< 0.05); however BNP was remained same in group M from 597 ± 999 pg/ml before surgery to 331 ± 843 pg/ml, and 331 ± 593 pg/ml.
CONCLUSION: The improvement of BNP and EF after coronary artery bypass grafting were significant in the patients with EF less than 30%.
CLINICAL IMPLICATIONS: Coronary artery bypass grafting for severely decreased EF could be beneficial in the patients with ischemic cardiomyopathy.
DISCLOSURE: Hitoshi Hirose, No Financial Disclosure Information; No Product/Research Disclosure Information