The counterpoint by Morris et al2 is a scholarly description of scientific inquiry and a paean to its virtues. There is no disagreement from us regarding its posits of credible evidence and the careful development of trial data. But the challenge lies in applying our existing knowledge to the exigencies of real life. What treatment should physicians offer once conventional measures are judged unsuccessful? Should nothing further be done, or, should alternative treatments with plausible benefit be administered? By steadfastly refusing to consider alternatives to dated studies, their essay fails to offer credible solutions for an evolving pandemic.