However, it was disappointing that the therapeutic intervention with CPAP was not described. How did the authors determine the therapeutic pressure setting? What was the mode of CPAP used? Equally important, was compliance with CPAP measured, and if so, was there a correlation between compliance and decrease in inflammatory mediators? It would have been especially interesting to see a graph of the dose-response curve, specifically the degree of CPAP compliance (hours on CPAP/hours of asleep) vs levels of serum high mobility group box-1 protein. Do those data exist, and could they be made available online?