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Correspondence |

Effect of Continuous Positive Airway Pressure on Inflammatory Markers FREE TO VIEW

Arn Eliasson, MD, FCCP
Author and Funding Information

From the Pulmonary, Critical Care, and Sleep Medicine, Walter Reed Army Medical Center.

Correspondence to: Arn Eliasson, MD, FCCP, Walter Reed Army Medical Center, 6900 Georgia Ave NW, Washington, DC 20307; e-mail: aheliasson@aol.com


Financial/nonfinancial disclosures: The authors have reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestpubs.org/site/misc/reprints.xhtml).


© 2010 American College of Chest Physicians


Chest. 2010;138(2):463. doi:10.1378/chest.10-0610
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To the Editor:

Wu and colleagues1 are to be congratulated on their interesting research recently published in CHEST (February 2010) that adds to our understanding of the mechanisms involved in the systemic inflammatory cascade associated with obstructive sleep apnea. The authors further demonstrated the salutary effects of continuous positive airway pressure (CPAP) in reversing the inflammatory response.

However, it was disappointing that the therapeutic intervention with CPAP was not described. How did the authors determine the therapeutic pressure setting? What was the mode of CPAP used? Equally important, was compliance with CPAP measured, and if so, was there a correlation between compliance and decrease in inflammatory mediators? It would have been especially interesting to see a graph of the dose-response curve, specifically the degree of CPAP compliance (hours on CPAP/hours of asleep) vs levels of serum high mobility group box-1 protein. Do those data exist, and could they be made available online?

Wu KM, Lin CC, Chiu CH, Liaw SF. Effect of treatment by nasal continuous positive airway pressure on serum high mobility group box-1 protein in obstructive sleep apnea. Chest. 2010;1372:303-309. [CrossRef] [PubMed]
 

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Wu KM, Lin CC, Chiu CH, Liaw SF. Effect of treatment by nasal continuous positive airway pressure on serum high mobility group box-1 protein in obstructive sleep apnea. Chest. 2010;1372:303-309. [CrossRef] [PubMed]
 
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