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Correspondence |

Safety of Ipratropium Bromide FREE TO VIEW

Saurabh Kumar Singh, MD, FCCP
Author and Funding Information

From the Department of Tuberculosis and Respiratory Diseases, Jawaharlal Nehru Medical College, Aligarh Muslim University.

Correspondence to: Saurabh Kumar Singh, MD, FCCP, Jawaharlal Nehru Medical College, Aligarh Muslim University, Department of Tuberculosis and Respiratory Diseases, Aligarh, UP, India, 202002; e-mail: doctorsaurabhsingh@gmail.com


Financial/nonfinancial disclosures: The author has reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestpubs.org/site/misc/reprints.xhtml).


© 2010 American College of Chest Physicians


Chest. 2010;138(1):235. doi:10.1378/chest.10-0182
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To the Editor:

I read the article by Ogale et al1 titled “Cardiovascular Events Associated With Ipratropium Bromide in COPD” in the recent issue of CHEST (January 2010). In the study, 93% of the cohorts who were exposed to anticholinergics were also using a short-acting β2 agonist. I think this may be the reason for the increased cardiovascular events in these patients. Metaanalysis done by Salpeter et al2 concluded that β2-agonist use in patients with obstructive airway disease increases the risk for adverse cardiovascular events.

Ogale SS, Lee TA, Au DH, Boudreau DM, Sullivan SD. Cardiovascular events associated with ipratropium bromide in COPD. Chest. 2010;1371:13-19. [CrossRef] [PubMed]
 
Salpeter SR, Ormiston TM, Salpeter EE. Cardiovascular effects of beta-agonists in patients with asthma and COPD: a meta-analysis. Chest. 2004;1256:2309-2321. [CrossRef] [PubMed]
 

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Ogale SS, Lee TA, Au DH, Boudreau DM, Sullivan SD. Cardiovascular events associated with ipratropium bromide in COPD. Chest. 2010;1371:13-19. [CrossRef] [PubMed]
 
Salpeter SR, Ormiston TM, Salpeter EE. Cardiovascular effects of beta-agonists in patients with asthma and COPD: a meta-analysis. Chest. 2004;1256:2309-2321. [CrossRef] [PubMed]
 
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