0
Original Research: SLEEP MEDICINE |

Leukocyte Telomere Length and Plasma Catestatin and Myeloid-Related Protein 8/14 Concentrations in Children With Obstructive Sleep Apnea

Jinkwan Kim, PhD; Seungkwan Lee, PhD; Rakesh Bhattacharjee, MD; Abdelnaby Khalyfa, PhD; Leila Kheirandish-Gozal, MD; David Gozal, MD, FCCP
Author and Funding Information

From the Section of Pediatric Sleep Medicine (Drs Kim, Khalyfa, Kheirandish-Gozal, and Gozal), Department of Pediatrics, University of Chicago, Chicago, IL; Kosair Children’s Hospital Research Institute (Dr Bhattacharjee), Department of Pediatrics, University of Louisville, Louisville, KY; and Department of Clinical Laboratory Science (Dr Lee), College of Health Science, Korea University, Seoul, Republic of Korea.

Correspondence to: David Gozal, MD, FCCP, Department of Pediatrics, Comer Children’s Hospital, Pritzker School of Medicine, The University of Chicago, 5721 S Maryland Ave, MC 8000, Ste K-160, Chicago, IL 60637; e-mail: dgozal@uchicago.edu


Funding/Support: Dr Gozal is supported by the National Institutes of Health [Grants HL-065270 and HL-086662]. Dr Bhattacharjee was supported by a sleep fellowship from Jazz Pharmaceuticals.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).


© 2010 American College of Chest Physicians


Chest. 2010;138(1):91-99. doi:10.1378/chest.09-2832
Text Size: A A A
Published online

Background:  Obstructive sleep apnea (OSA) is common in children and leads to multiple end-organ morbidities induced by the cumulative burden of oxidative stress and inflammation. Leukocyte telomere length (LTL) reflects not only chronologic age but also the burden of disease. We hypothesized that LTL would be decreased in children with OSA.

Methods:  Two hundred thirteen children (mean age, 7.7 ± 1.4 years) were included after a sleep study and a morning blood sample. LTL was examined by quantitative polymerase chain reaction in a case-control setting involving 111 OSA cases and 102 controls. Myeloid-related protein (MRP) 8/14 and catestatin plasma levels also were assayed using enzyme-linked immunosorbent assay.

Results:  Log LTL was significantly increased and OSA severity dependently increased in children (P = .012), was positively associated with apnea-hypopnea index (AHI) (r = 0.236; P < .01), and was inversely correlated with age (r = −0.145; P < .05). In a multivariate regression model, LTL was independently associated with AHI (β = 0.28; P = .002) after adjusting for age, sex, BMI z score, and race. Children with OSA exhibited higher BP (P < .05), lower plasma catestatin (P = .009), and higher MRP 8/14 levels (P < .001) than controls. Of note, children with the lowest plasma catestatin levels (< 1.39 ng/mL) had 5.2-fold increased odds of moderate-to-severe OSA (95% CI, 1.19-23.4 ng/mL; P < .05) after adjusting for confounding variables.

Conclusions:  In pediatric OSA, LTL is longer rather than shorter. Children with OSA have reduced plasma catestatin levels and increased BP along with increased MRP 8/14 levels that exhibit AHI dependencies. Thus, catestatin and MRP 8/14 levels may serve as biomarkers for cardiovascular risk in the context of pediatric OSA. However, the implications of increased LTL in children with OSA remain to be defined.

Figures in this Article

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
Guidelines
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543