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Recent Advances in Chest Medicine |

Oxygen Therapy for Patients With COPD: Current Evidence and the Long-Term Oxygen Treatment Trial

James K. Stoller, MD, MS, FCCP; Ralph J. Panos, MD, FCCP; Samuel Krachman, DO, FCCP; Dennis E. Doherty, MD, FCCP; Barry Make, MD, FCCP; the Long-term Oxygen Treatment Trial Research Group
Author and Funding Information

From the Respiratory Institute (Dr Stoller), Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, OH; Pulmonary, Critical Care, and Sleep Division (Dr Panos), Cincinnati Veterans Administration Medical Center, Cincinnati, OH; Sleep Disorders Center (Dr Krachman), Division of Pulmonary and Critical Care, Temple University, Philadelphia, PA; Division of Pulmonary, Critical Care, and Sleep Medicine (Dr Doherty), Veterans Administration Medical Center and University of Kentucky, Lexington, KY; and Division of Pulmonary Sciences and Critical Care Medicine (Dr. Make), National Jewish Health and University of Colorado, Denver, CO.

Correspondence to: Barry Make, MD, FCCP, National Jewish Health, 1400 Jackson St, K729, Denver, CO 80206; e-mail: makeb@njhealth.org


Funding/Support: This project is supported through federal funding from the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services [contracts HHSN268200736183C, HHSN268200736184C, HSN268200736185C, HHSN268200736186C, HHSN268200736187C, HHSN268200736188C, HHSN268200736189C, HHSN268200736190C, HHSN268200736191C, HHSN268200736192C, HHSN268200736193C, HHSN268200736194C, HHSN268200736195C, HHSN268200736196C, HHSN268200736197C, Y1-HR-7019-01, and Y1-HR-8076-01] in cooperation with the Centers for Medicare and Medicaid Services, Department of Health and Human Services.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).


© 2010 American College of Chest Physicians


Chest. 2010;138(1):179-187. doi:10.1378/chest.09-2555
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Long-term use of supplemental oxygen improves survival in patients with COPD and severe resting hypoxemia. However, the role of oxygen in symptomatic patients with COPD and more moderate hypoxemia at rest and desaturation with activity is unclear. The few long-term reports of supplemental oxygen in this group have been of small size and insufficient to demonstrate a survival benefit. Short-term trials have suggested beneficial effects other than survival in patients with COPD and moderate hypoxemia at rest. In addition, supplemental oxygen appeared to improve exercise performance in small short-term investigations of patients with COPD and moderate hypoxemia at rest and desaturation with exercise, but long-term trials evaluating patient-reported outcomes are lacking. This article reviews the evidence for long-term use of supplemental oxygen therapy and provides a rationale for the National Heart, Lung, and Blood Institute Long-term Oxygen Treatment Trial. The trial plans to enroll subjects with COPD with moderate hypoxemia at rest or desaturation with exercise and compare tailored oxygen therapy to no oxygen therapy.

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