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Original Research: CYSTIC FIBROSIS |

Clinical Outcome for Cystic Fibrosis Patients Infected With Transmissible Pseudomonas aeruginosa: An 8-Year Prospective Study

Andrew M. Jones, MD; Mary E. Dodd, DSc; Julie Morris, PhD; Cathy Doherty, PhD; John R. W. Govan, PhD; A. Kevin Webb, MD
Author and Funding Information

From the Manchester Adult Cystic Fibrosis Centre (Drs Jones, Webb, and Dodd), and Medical Statistics (Dr Morris), University Hospitals South Manchester NHS Foundation Trust, Wythenshawe, Manchester, England; and Medical Microbiology (Drs Doherty and Govan), University of Edinburgh Medical School, Edinburgh, Scotland.

Correspondence to: Andrew M. Jones, MD, Manchester Adult Cystic Fibrosis Centre, University Hospitals South Manchester NHS Foundation Trust, Southmoor Rd, Manchester, M23 9LT, England; e-mail: andrew.jones@uhsm.nhs.uk


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestpubs.org/site/misc/reprints.xhtml).


© 2010 American College of Chest Physicians


Chest. 2010;137(6):1405-1409. doi:10.1378/chest.09-2406
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Background:  Although there is now compelling evidence for cross-infection by strains of Pseudomonas aeruginosa at some specialist (cystic fibrosis [CF]) centers, the clinical impact of infection by transmissible strains is unclear.

Methods:  In an 8-year prospective study, we compared the clinical outcome of two groups of patients with CF infected by transmissible (n = 28) and sporadic strains (n = 52) of P aeruginosa.

Results:  There were no differences between the two groups in survival, annual changes in spirometry, or BMI. There were differences in requirements for IV antibiotic treatment (mean [SD]: 29.3 [21.9] days vs 53.1 [32.5] days) and hospitalization (median [range]: 11.6 [1.1, 49.3] days vs 23.3 [5.5, 103.6] days) between patients infected with sporadic and transmissible strains of P aeruginosa, respectively.

Conclusions:  We conclude that infection by transmissible P aeruginosa does not increase mortality but is associated with increased health-care and antibiotic use for patients with CF.


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