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Reversible Cardiac Dysfunction Associated With Pandemic 2009 Influenza A(H1N1)

Seth S. Martin, MD; Caroline L. Hollingsworth, MD, MPH; Stephanie G. Norfolk, MD; Cameron R. Wolfe, MBBS; John W. Hollingsworth, MD
Author and Funding Information

Correspondence to: John W. Hollingsworth, MD, Duke University Medical Center, Box 103004, Durham, NC 27710; e-mail: holli017@mc.duke.edu


Funding/Support: This work was supported by the National Institutes of Health [Grants ES16126, ES16659, AI81672].

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestpubs.org/site/misc/reprints.xhtml).


© 2010 American College of Chest Physicians


Chest. 2010;137(5):1195-1197. doi:10.1378/chest.10-0032
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Historical influenza A epidemics have carried elevated rates of cardiovascular disease, including transient cardiac dysfunction. Whether such an association holds for the novel influenza A strain, pandemic 2009 influenza A(H1N1) [A(H1N1)], remains unknown. We report an index case of transient cardiac dysfunction associated with A(H1N1) infection. Next, we reviewed 123 sequential cases of patients hospitalized with pandemic A(H1N1) at a single academic medical center in the United States from April 1, 2009, through October 31, 2009. We identified that 4.9% (6/123) of patients had either new or worsened left ventricular dysfunction. These cases ranged in age from 23 to 51 years, and all had preexisting medical conditions. ICU level care was required in 83% (5/6) of the cases. Sixty-seven percent (4/6) of the cases had follow-up echocardiograms, and left ventricular function improved in all four. We conclude that potentially reversible cardiac dysfunction is a relatively common complication associated with hospitalized pandemic A(H1N1) influenza.


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