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Occupational Asthma Due to Colistin in a Pharmaceutical Worker

Susana Gómez-Ollés, PhD; Federico Madrid-San Martín; María-Jesús Cruz; Xavier Muñoz, MD, PhD
Author and Funding Information

From Servei de Pneumologia (Drs Gómez-Ollés, Cruz, and Muñoz), Hospital Universitari Vall d’Hebron; CIBER Enfermedades Respiratorias (CIBERES) (Drs Gómez-Ollés, Cruz, and Muñoz), Instituto de Salud Carlos III; Departamento de Enfermedades (Dr Madrid-San Martín), Profesionales de ASEPEYO Mutua de Accidentes de Trabajo y Enfermedades Profesionales de la Seguridad Social; and Departament de Biologia cellular, Fisiologia, Immunologia (Dr Muñoz), Universidad Autònoma de Barcelona, Barcelona, Spain.

Correspondence to: Dr Xavier Muñoz, Servei de Pneumologia, Hospital Universitari Vall d’Hebron, Passeig Vall d’Hebron, 119, 08035 Barcelona, Spain; e-mail: xmunoz@vhebron.net


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestpubs.org/site/misc/reprints.xhtml).


© 2010 American College of Chest Physicians


Chest. 2010;137(5):1200-1202. doi:10.1378/chest.09-1881
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To our knowledge, this is the first case report of a 24-year-old man working in a pharmaceutical company transporting and storing raw materials who developed occupational asthma (OA) to colistin. The specific inhalation challenge confirmed the diagnosis of OA to colistin. Specific IgE was not detected, because dot-blot analysis was negative at all colistin concentrations tested. To our knowledge, OA due to a peptide antibiotic has not previously been described. This antibiotic should be listed as a trigger of OA.

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