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Novel Asthma-Associated Genes From Genome-Wide Association Studies: What Is Their Significance?

Michael Kabesch, MD
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From the Center for Paediatrics, Clinic for Paediatric Pneumology and Neonatology, Hannover Medical School, Hannover, Germany.

Correspondence to: Michael Kabesch, MD, Center for Paediatrics, Clinic for Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany; e-mail: Kabesch.Michael@mh-hannover.de


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestpubs.org/site/misc/reprints.xhtml).


© 2010 American College of Chest Physicians


Chest. 2010;137(4):909-915. doi:10.1378/chest.09-1554
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Asthma is a complex syndrome leading to the easily recognizable clinical feature of wheezing. This is believed to be caused by inflammation, constriction of the airway smooth muscles, and extensive mucus secretion. However, the mechanisms initiating and maintaining these simple clinical features are not well understood, even after 100 years of asthma research. Still worse is our understanding of why certain individuals develop asthma and others do not.

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