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Correspondence |

The Role of Aldosterone in Pulmonary Venous Hypertension FREE TO VIEW

Harrison W. Farber, MD, FCCP; Allan J. Walkey, MD; Mir M. Alikhan, MD
Author and Funding Information

From the Boston University Medical Center.

Correspondence to: Mir M. Alikhan, MD, 715 Albany St, Evans 124, Boston, MA 02118; e-mail: mir.alikhan@bmc.org


Financial/nonfinancial disclosures: The authors have reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).


© 2010 American College of Chest Physicians


Chest. 2010;137(2):502. doi:10.1378/chest.09-1864
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To the Editor:

We read with interest the recent article in CHEST (July 2009) by Robbins et al1 demonstrating an association between the metabolic syndrome and the existence of pulmonary venous hypertension. Recent research has also demonstrated an association between serum aldosterone, a known cause of left ventricular dysfunction and remodeling, and the metabolic syndrome.2-4 Thus, it is possible that increased circulating aldosterone might be independently associated with the risk for pulmonary venous hypertension. Do the authors have data examining aldosterone or renin activity in their subjects?

Robbins IM, Newman JH, Johnson RF, et al. Association of the metabolic syndrome with pulmonary venous hypertension. Chest. 2009;1361:31-36. [CrossRef] [PubMed]
 
Rossi GP, Di Bello V, Ganzaroli C, et al. Excess aldosterone is associated with alterations of myocardial texture in primary aldosteronism. Hypertension. 2002;401:23:27. [CrossRef] [PubMed]
 
Stowasser M, Sharman J, Leano R, et al. Evidence for abnormal left ventricular structure and function in normotensive individuals with familial hyperaldosteronism type I. J Clin Endocrinol Metab. 2005;909:5070-5076. [CrossRef] [PubMed]
 
Sowers JR, Whaley-Connell A, Epstein M. Narrative review: the emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertension. Ann Intern Med. 2009;15011:776-783. [PubMed]
 

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References

Robbins IM, Newman JH, Johnson RF, et al. Association of the metabolic syndrome with pulmonary venous hypertension. Chest. 2009;1361:31-36. [CrossRef] [PubMed]
 
Rossi GP, Di Bello V, Ganzaroli C, et al. Excess aldosterone is associated with alterations of myocardial texture in primary aldosteronism. Hypertension. 2002;401:23:27. [CrossRef] [PubMed]
 
Stowasser M, Sharman J, Leano R, et al. Evidence for abnormal left ventricular structure and function in normotensive individuals with familial hyperaldosteronism type I. J Clin Endocrinol Metab. 2005;909:5070-5076. [CrossRef] [PubMed]
 
Sowers JR, Whaley-Connell A, Epstein M. Narrative review: the emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertension. Ann Intern Med. 2009;15011:776-783. [PubMed]
 
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