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Correspondence |

The Effect of Specific Allergen Inhalation on Adipokine Level: Can Adiponectin Oligomers and Hormones Be a Factor? FREE TO VIEW

Duygu Ozol, MD
Author and Funding Information

From the Department of Pulmonology, Fatih University Faculty of Medicine.

Correspondence to:Duygu Ozol, MD, Department of Pulmonology, Fatih University Faculty of Medicine, Hosdere cad. no: 145 06510 Ankara, Turkey; e-mail: dozol@hotmail.com


Financial/nonfinancial disclosures:The author has reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).


© 2010 American College of Chest Physicians


Chest. 2010;137(2):498-499. doi:10.1378/chest.09-1256
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Published online

To the Editor:

I read with great interest the original research article in CHEST (February 2009) by Sood et al.1 The authors searched the effect of specific allergen inhalation on adiponectin, leptin, and the adiponectin-to-leptin ratio in mild asthmatic patients and found that specific allergen inhalation had no effect on serum adipokine levels. Previously, Unal et al2 showed that serum leptin levels were significantly higher in 26 adult patients with allergic rhinitis during a symptomatic period than in a control group. Also, Radon et al’s3 epidemiologic findings confirmed a linear positive association between serum leptin level and prevalence of allergic sensitization (highest vs lowest quartile odds ratio 6.7, 95% CI 2.0-22.4) especially in subjects with farm contact. In combination with experimental data in animals, these findings suggest a link between adipokines and allergy.

I wish to express my concerns about two aspects of their work. As it has been speculated that sex hormones could affect adiponectin levels, I think they sought more to minimize potential confounders. In his previous study, Sood et al4 showed that in women, but not men, a lower serum adiponectin concentration is associated with asthma. Estrogen and progesterone may affect the adiponectin concentration by controlling adipose tissue metabolism and estrogen, which has been shown to alter the action of lipoprotein lipase and hormone-sensitive lipase in adipocytes. There is also in vitro evidence that estrogen decreased adiponectin expression in adipocytes.5 In the present study, as most of the subjects were women in the premenopausal stage, this phase of their menstrual cycle might also be important.

Second, in the present study only total adiponectin concentration had been measured. Adiponectin circulates as multiple oligomer forms such as low-molecular-weight trimer, medium-molecular-weight hexamer, and high-molecular-weight (HMW) multimer (12-18 mers).6 It has been demonstrated that the lower plasma concentration of adiponectin in men could be due to a smaller amount of the HMW form of adiponectin. Secretion of HMW adiponectin has been reported to decline in response to testosterone.7 In a cross-sectional study of 32 healthy women (12 premenopausal, 10 postmenopausal, and 10 early pregnant), they found that serum concentrations of total and HMW adiponectin were highest in postmenopausal women and lowest in pregnant women with regard to estrogen level.8 In summary, application of more strict inclusion criteria considering sex hormones and investigating circulating oligomeric isoforms of adiponectin could help us to understand underlying mechanisms for asthma and adipokines better.

Sood A, Qualls C, Seagrave J, et al. Effect of specific allergen inhalation on serum adiponectin in human asthma. Chest. 2009;1352:287-294. [CrossRef] [PubMed]
 
Unal M, Eskandari G, Muşlu N, Pata YS, Akbaş Y. Serum leptin levels in patients with allergic rhinitis. Otolaryngol Head Neck Surg. 2006;1342:331-333. [CrossRef] [PubMed]
 
Radon K, Schulze A, Schierl R, Dietrich-Gümperlein G, Nowak D, Jörres RA. Serum leptin and adiponectin levels and their association with allergic sensitization. Allergy. 2008;6311:1448-1454. [CrossRef] [PubMed]
 
Sood A, Cui X, Qualls C, et al. Association between asthma and serum adiponectin concentration in women. Thorax. 2008;6310:877-882. [CrossRef] [PubMed]
 
Dyck DJ. Adipokines as regulators of muscle metabolism and insulin sensitivity. Appl Physiol Nutr Metab. 2009;343:396-402. [CrossRef] [PubMed]
 
Radjainia M, Wang Y, Mitra AK. Structural polymorphism of oligomeric adiponectin visualized by electron microscopy. J Mol Biol. 2008;3812:419-430. [CrossRef] [PubMed]
 
Nishizawa H, Shimomura I, Kishida K, et al. Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein. Diabetes. 2002;519:2734-2741. [CrossRef] [PubMed]
 
Leung KC, Xu A, Craig ME, Martin A, Lam KS, O’Sullivan AJ. Adiponectin isoform distribution in women—relationship to female sex steroids and insulin sensitivity. Metabolism. 2009;582:239-245. [CrossRef] [PubMed]
 

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References

Sood A, Qualls C, Seagrave J, et al. Effect of specific allergen inhalation on serum adiponectin in human asthma. Chest. 2009;1352:287-294. [CrossRef] [PubMed]
 
Unal M, Eskandari G, Muşlu N, Pata YS, Akbaş Y. Serum leptin levels in patients with allergic rhinitis. Otolaryngol Head Neck Surg. 2006;1342:331-333. [CrossRef] [PubMed]
 
Radon K, Schulze A, Schierl R, Dietrich-Gümperlein G, Nowak D, Jörres RA. Serum leptin and adiponectin levels and their association with allergic sensitization. Allergy. 2008;6311:1448-1454. [CrossRef] [PubMed]
 
Sood A, Cui X, Qualls C, et al. Association between asthma and serum adiponectin concentration in women. Thorax. 2008;6310:877-882. [CrossRef] [PubMed]
 
Dyck DJ. Adipokines as regulators of muscle metabolism and insulin sensitivity. Appl Physiol Nutr Metab. 2009;343:396-402. [CrossRef] [PubMed]
 
Radjainia M, Wang Y, Mitra AK. Structural polymorphism of oligomeric adiponectin visualized by electron microscopy. J Mol Biol. 2008;3812:419-430. [CrossRef] [PubMed]
 
Nishizawa H, Shimomura I, Kishida K, et al. Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein. Diabetes. 2002;519:2734-2741. [CrossRef] [PubMed]
 
Leung KC, Xu A, Craig ME, Martin A, Lam KS, O’Sullivan AJ. Adiponectin isoform distribution in women—relationship to female sex steroids and insulin sensitivity. Metabolism. 2009;582:239-245. [CrossRef] [PubMed]
 
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