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Original Research: SLEEP MEDICINE |

Effect of Treatment by Nasal Continuous Positive Airway Pressure on Serum High Mobility Group Box-1 Protein in Obstructive Sleep Apnea

Kun-Ming Wu, MD; Ching-Chi Lin, MD, FCCP; Chung-Hsin Chiu, BS; Shwu-Fang Liaw, MS
Author and Funding Information

From the Chest Division, Department of Internal Medicine, Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan.

Correspondence to: Ching-Chi Lin, MD, FCCP, Chest Section, Department of Internal Medicine, Mackay Memorial Hospital, 92, Sec 2, Chung Shan North Road, Taipei, Taiwan; e-mail: cclin@ms2.mmh.org.tw


Funding/Support: This research was supported by the National Science Council [96-2314-B-195-015].

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).


© 2010 American College of Chest Physicians


Chest. 2010;137(2):303-309. doi:10.1378/chest.09-0936
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Background:  Serum levels of high mobility group box-1 protein (HMGB1) are increased in a variety of inflammatory disorders. Obstructive sleep apnea syndrome (OSAS) is associated with inflammation secondary to chronic intermittent hypoxia, but HMGB1 levels in treated and untreated OSAS have not been evaluated.

Methods:  Twenty healthy subjects and 30 subjects with moderately severe or severe OSAS who desired nasal continuous positive airway pressure (CPAP) treatment were enrolled. Serum levels of HMGB1 and nitric oxide derivative (NOx) from peripheral blood samples were measured, and all subjects underwent a sleep study. These studies were repeated 2 months after nasal CPAP treatment in the patients with OSAS.

Results:  In OSAS before nasal CPAP treatment, the serum level of HMGB1 was higher but that of NOx was lower than those levels of normal subjects. The HMGB1 levels correlated negatively with NOx levels in subjects with OSAS. After nasal CPAP treatment, the HMGB1 and NOx returned to normal levels.

Conclusion:  Elevated HMGB1 levels and reduced NOx levels in patients with OSAS normalized after nasal CPAP treatment.

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