A nonproductive cough, wheezing on exertion, and night sweats developed in a 30-year-old African-American woman. In addition, she developed cervical, inguinal, and epitrochlear lymphadenopathy. She had no history of tuberculosis or tuberculosis exposure; a tuberculin skin test was performed and was negative. She had no history of cigarette smoking, alcohol abuse, or illicit drug use. She had no family history of sarcoidosis. The patient was referred to a general surgeon, who deferred performing a lymph node biopsy. Concurrently, the patient began to develop vaginal itching and irritation. She was treated with numerous courses of antibiotics by her gynecologist without relief of her symptoms. In light of continuing complaints, she underwent an extensive workup of tests for sexually transmitted diseases, all of which were negative.