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Recent Advances in Chest Medicine |

Coagulopathy in Critically III Patients: Part 2–Soluble Clotting Factors and Hemostatic Testing

Arthur P. Wheeler, MD, FCCP; Todd W. Rice, MD, MSc
Author and Funding Information

From the Medical Intensive Care Unit, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN.

Correspondence to: Arthur P. Wheeler, MD, FCCP, T-1210 MCN Vanderbilt Medical Center, Nashville, TN 37232-2650; e-mail: art.wheeler@vanderbilt.edu


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).


© 2010 American College of Chest Physicians


Chest. 2010;137(1):185-194. doi:10.1378/chest.08-2535
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This manuscript provides an overview of how to interpret in vitro clotting studies and how to select studies to evaluate patients with bleeding disorders in the ICU. It provides a practical approach to understanding the complex subject of clotting factor abnormalities, including the most common problems of preanalytical error and anticoagulation therapy. Limitations and pitfalls of diagnostic testing are highlighted.

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