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Etanercept-Induced Lupus Erythematosus Presenting as a Unilateral Pleural Effusion

Jafar Abunasser, MD; Faripour A. Forouhar, MD; Mark L. Metersky, MD, FCCP
Author and Funding Information

*From the Division of Pulmonary and Critical Care Medicine (Drs. Abunasser and Metersky) and the Department of Anatomic Pathology and Laboratory Medicine (Dr. Forouhar), University of Connecticut School of Medicine, Farmington, CT.

Correspondence to: Mark L. Metersky, MD, FCCP, Division of Pulmonary and Critical Care Medicine, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030-1321; e-mail: Metersky@nso.uchc.edu

Dr. Metersky has served on an advisory board/speaker's bureau for the following pharmaceutical companies: Advanced Life Sciences, Genetech, Novartis, Pfizer, and Wyeth. Dr. Abunasser and Dr. Forouhar have no conflicts of interest to declare.


Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).


Chest. 2008;134(4):850-853. doi:10.1378/chest.08-0034
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A 72-year-old man receiving etanercept for the treatment of psoriatic arthritis had an exudative pleural effusion with nonspecific fluid analysis and pleural biopsy findings. He was ultimately found to have drug-induced lupus erythematosus due to the etanercept. The spectrum of autoimmune disease due to the use of tumor necrosis factor inhibitors is reviewed.

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