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Original Research: LUNG CANCER |

Expression of Ig-Like Transcript 4 Inhibitory Receptor in Human Non-small Cell Lung Cancer

Yuping Sun, PhD; Jie Liu, MD; Ping Gao, MD; Yunshan Wang, PhD; Chuanyong Liu, MD
Author and Funding Information

*From Jinan Central Hospital, Shandong University, Jinan, People's Republic of China.

Correspondence to: Yuping Sun, PhD, Jinan Central Hospital, Shandong University, Jinan, Shandong 250013, People's Republic of China; e-mail: sunyupingsyp@hotmail.com


This work was performed at Jinan Central Hospital, Shandong University.

The authors have no conflicts of interest to disclose.

Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).


Chest. 2008;134(4):783-788. doi:10.1378/chest.07-1100
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Background:  Human Ig-like transcript 4 (ILT-4) is a member of the inhibitory receptor family for immune function. Little is known about the expression levels of ILT-4 in tumor cells.

Methods:  We have studied the expression levels of ILT-4 both in vitro in cancer cell lines and in vivo in tumor tissues from 70 patients with non-small cell lung cancer (NSCLC) by reverse transcriptase-polymerase chain reaction, fluorescence-activated cell sorting, and immunohistochemical analysis.

Results:  Three cancer cell lines (H1299, A549, and U1810) express ILT-4 messenger RNA, and only two cell lines (H1299 and A549) express ILT-4 protein on the cell surface. Approximately 37.1% of 70 tumor tissue samples express ILT-4, which is localized in the cell membrane and cytoplasm. In addition, tumor cells and stromal and plasma cells also express ILT-4. The number of infiltrating lymphoid cells in the tumor tissues that express B7-H3 was much lower than those that did not, but there is no significant correlation between ILT-4 expression and disease progression including nodal metastasis.

Conclusions:  These findings suggest that ILT-4 is frequently expressed in both tumor and stromal cells of NSCLC, and it might play an important role in regulation of the host immune system.

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