Immunosuppressed individuals, such as organ transplant recipients, can have hyperinfection syndrome and disseminated disease. These two manifestations of disease occur mainly in immunocompromised individuals. In hyperinfection syndrome, the noninfectious rhabditiform larvae mature into infectious filariform larvae within the GI tract. These larvae penetrate the perianal skin or the colonic mucosa rather than pass in the feces, and travel hematogenously back to the lungs. This syndrome is limited mainly to the GI tract, circulation, and lungs. In disseminated disease, the filariform larvae hematogenously infect other organs not involved in the normal helminthic life cycle such as the heart, liver, CNS, kidneys, and endocrine glands, causing inflammation and organ dysfunction. Due to their invasive nature, the Strongyloides larvae can be found in most body fluids including sputum, urine, semen, ascites, and cerebrospinal fluid.