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Original Research: COUGH |

Impact of Cough Across Different Chronic Respiratory Diseases*: Comparison of Two Cough-Specific Health-Related Quality of Life Questionnaires

Liam Polley, MB; Nurman Yaman, MB; Liam Heaney, MD; Chris Cardwell, PhD; Eimear Murtagh, MB; John Ramsey, MB, MA; Joseph MacMahon, MB; Richard W. Costello, MD; Lorcan McGarvey, MD
Author and Funding Information

*From the Regional Respiratory Centre (Drs. Polley, Yaman, and MacMahon) and Department of Radiology (Drs. Murtagh and Ramsey), Belfast City Hospital, Respiratory Research Group (Drs. Heaney and McGarvey), and Department of Epidemiology and Public Health (Dr. Cardwell), The Queen’s University of Belfast, Northern Ireland; and Department of Medicine (Dr. Costello), Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.

Correspondence to: Lorcan McGarvey, MD, Department of Medicine, The Queen’s University of Belfast, Northern Ireland; e-mail: l.mcgarvey@qub.ac.uk



Chest. 2008;134(2):295-302. doi:10.1378/chest.07-0141
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Background: Cough is a prominent symptom across a range of common chronic respiratory diseases and impacts considerably on patient health status.

Methods: We undertook a cross-sectional comparison of scores from two cough-specific health-related quality of life (HRQoL) questionnaires, the Leicester Cough Questionnaire (LCQ), and the Cough Quality of Life Questionnaire (CQLQ), together with a generic HRQoL measure, the EuroQol. Questionnaires were administered to and spirometry performed on 147 outpatients with chronic cough (n = 83), COPD (n = 18), asthma (n = 20), and bronchiectasis (n = 26).

Results: There was no significant difference in the LCQ and CQLQ total scores between groups (p = 0.24 and p = 0.26, respectively). Exploratory analyses of questionnaire subdomains revealed differences in psychosocial issues and functional impairment between the four groups (p = 0.01 and p = 0.05, respectively). CQLQ scores indicated that chronic coughers have more psychosocial issues than patients with bronchiectasis (p = 0.03) but less functional impairment than COPD patients (p = 0.04). There was a significant difference in generic health status across the four disease groups (p = 0.04), with poorest health status in COPD patients. A significant inverse correlation was observed between CQLQ and LCQ in each disease group (chronic cough r = − 0.56, p < 0.001; COPD r = − 0.49, p = 0.04; asthma r = − 0.94, p < 0.001; and bronchiectasis r = − 0.88, p < 0.001). There was no correlation between cough questionnaire scores and FEV1 in any group, although a significant correlation between EuroQol visual analog scale component and FEV1 (r = 0.639, p = 0.004) was observed in COPD patients.

Conclusion: Cough adversely affects health status across a range of common respiratory diseases. The LCQ and CQLQ can each provide important additional information concerning the impact of cough.

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