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Beneficial Response to Macrolide Antibiotic in a Patient With Desquamative Interstitial Pneumonia Refractory to Corticosteroid Therapy*

Alexey Knyazhitskiy, MD; Richard G. Masson, MD, FCCP; Richard Corkey, MD; Jane Joiner, MD
Author and Funding Information

*From the Departments of Internal Medicine (Drs. Knyazhitskiy and Joiner), Pulmonary Medicine (Dr. Masson), and Pathology (Dr. Corkey), MetroWest Medical Center, Framingham, MA.

Correspondence to: Alexey Knyazhitskiy, MD, MetroWest Medical Center, Internal Medicine, 115 Lincoln St, Framingham, MA 01702; e-mail: aknyazhitskiy@mwmc.com


Chest. 2008;134(1):185-187. doi:10.1378/chest.07-2786
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Macrolide antibiotics have been shown to have a beneficial effect in a number of pulmonary conditions that are characterized by inflammation, including cystic fibrosis, asthma, and cryptogenic organizing pneumonia. We report the first case of desquamative interstitial pneumonia (DIP) showing a favorable response to treatment with clarithromycin. If confirmed, this observation would add DIP to the list of pulmonary disorders that are amenable to the beneficial antiinflammatory effects of macrolides.

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