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Editorials: POINT/COUNTERPOINT EDITORIALS |

Point: Evidence-Based Medicine Has a Sound Scientific Base

Paul J. Karanicolas, MD; Regina Kunz, MD, PhD; Gordon H. Guyatt, MD, MSc, FCCP
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Affiliations: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada,  Basel Institute for Clinical Epidemiology, University Hospital Basel, Basel, Switzerland,  Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada

Correspondence to: Paul J. Karanicolas, MD, Department of Clinical Epidemiology and Biostatistics, McMaster University Medical Center, 1200 Main St W, Room 2C12, Hamilton, ON, L8N 3Z5, Canada; e-mail: pjkarani@uwo.ca



Chest. 2008;133(5):1067-1071. doi:10.1378/chest.08-0068
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The scientific basis of evidence-based medicine (EBM) rests on three principles. First, systematic summaries of the highest quality available evidence should inform clinical decisions. Second, wise use of the literature requires a sophisticated hierarchy of evidence. Finally, evidence alone is never sufficient to make clinical decisions; rather, it requires trading off benefits and risks, inconvenience, and costs, and in doing so considering patients' values and preferences.

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