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Aerosolized β-Adrenergic Agonist Therapy Reduces Pulmonary Edema Following Lung Surgery

Michael A. Matthay, MD, FCCP; Carolyn S. Calfee, MD
Author and Funding Information

San Francisco, CA

Correspondence to: Michael A. Matthay, MD, FCCP, 505 Parnassus Ave, Moffitt Hospital, M-917, University of California, San Francisco, CA 94143-0624; e-mail: michael.matthay@ucsf.edu



Chest. 2008;133(4):833-835. doi:10.1378/chest.07-2788
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Several experimental studies14 have provided convincing evidence that β2-adrenergic agonist therapy can accelerate the removal of alveolar edema fluid in both normal and injured lungs, primarily by a cyclic adenosine monophosphate-mediated increase in the vectorial transport of sodium and chloride across both alveolar epithelial type I and type II cells. In addition, a placebo-controlled trial5 demonstrated that IV β2-adrenergic therapy with salbutamol decreases extravascular lung water in patients with pulmonary edema from acute lung injury. In this issue of CHEST (see page 845), there is important new evidence that aerosolized β2-adrenergic agonist therapy can accelerate the resolution of pulmonary edema in surgical patients who have undergone pulmonary resection.6

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