Management of uvular angioedema is primarily guided by clinical experience with angioedema of other anatomic distributions, as opposed to clinical trials. The primary therapeutic goal is prevention of airway obstruction. Equipment and expertise for dealing with a difficult airway should be immediately available; if orotracheal intubation fails, a surgical airway may be required. Upper airway structures should be visualized via fiberoptic examination. Alternatively, lateral radiographs of the neck or other radiologic imaging may allow visualization of the degree of soft-tissue swelling. The syndrome is often initially managed medically with diphenhydramine, histamine blockers, steroids, and epinephrine, depending on severity. There is evidence that uvular edema arising from other etiologies may be managed with nebulized racemic epinephrine if the patient is in distress. This intervention, however, should not delay establishment of an airway. Direct mechanical decompression may be required in severe cases. There are anecdotal reports of the use of needle decompression of the uvula to decrease inflammation. In the setting of failure of medical therapy, partial uvulectomy should be considered. Long-term therapy consists of avoidance of possible precipitating agents and, in this case, possibly avoidance of other compounds of similar structure.