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Original Research: NEOPLASTIC DISEASE |

Marginal Zone B-Cell Lymphoma of Bronchus-Associated Lymphoid Tissue*: Imaging Findings in 21 Patients

Young A Bae, MD; Kyung Soo Lee, MD; Joungho Han, MD; Young-Hyeh Ko, MD; Byung-Tae Kim, MD; Myung Jin Chung, MD; Tae Sung Kim, MD
Author and Funding Information

*From the Departments of Radiology (Drs. Bae, Lee, Chung, and T.S. Kim), Diagnostic Pathology (Drs. Han and Ko), and Nuclear Medicine (Dr. B.T. Kim), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Correspondence to: Kyung Soo Lee, MD, Department of Radiology, Samsung Medical Center, 50, Ilwon-Dong, Kangnam-Ku, Seoul 135-710, Korea; e-mail: kyungs.lee@samsung.com



Chest. 2008;133(2):433-440. doi:10.1378/chest.07-1956
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Background: Few articles have been published on imaging findings of marginal zone B-cell lymphoma of bronchus-associated lymphoid tissue (BALT) of the lung. We present CT scan and 18F-fluorodeoxyglucose (FDG) PET scan findings of the disease.

Methods: From March 1995 to February 2007, 21 pretreatment patients (male patients, 9; female patients, 12; age range, 35 to 76 years; mean [± SD] age, 54 ± 10.4 years) were seen who had pathologic diagnoses of marginal zone B-cell lymphoma of BALT. After CT scans were reviewed searching for specific patterns and distribution of parenchymal lung lesions, patients were classified as having the following four different patterns: (1) single nodular or consolidative; (2) multiple nodular or areas of consolidation; (3) bronchiectasis and bronchiolitis; and (4) diffuse interstitial lung disease (DILD) patterns. In six patients, in whom PET/CT scanning was performed, the pattern and the extent of maximum standardized uptake values (mSUVs) of FDG uptake were described.

Results: A single nodular or consolidative pattern was observed in 7 of 21 (33%) patients, multiple nodular or areas of consolidation were observed in 9 patients (43%), bronchiectasis and bronchiolitis were observed in 3 patients (14%), and DILD was observed in 2 patients (10%). On PET scans (n = 6), lesions showed heterogeneous FDG uptake in five patients and homogeneous uptake in one patient, with mSUVs ranging from 2.2 to 6.3 (mean mSUV, 4.2 ± 1.48).

Conclusions: Marginal zone B-cell lymphomas of BALT manifest diverse patterns of lung abnormality on CT scans, but single or multiple nodules or areas of consolidation are the main patterns that occur in a majority (76%) of patients. Most lesions show heterogeneous but identifiable FDG uptake on PET scans.

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