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Original Research: COPD |

Prevalence of COPD in Five Colombian Cities Situated at Low, Medium, and High Altitude (PREPOCOL Study)*

Andrés Caballero, MD; Carlos A. Torres-Duque, MD; Claudia Jaramillo, MD; Fabio Bolívar, MD; Fernando Sanabria, MD; Patricia Osorio, MD; Carlos Orduz, MD; Diana P. Guevara; Darío Maldonado, MD, FCCP
Author and Funding Information

*From the Asociación Colombiana de Neumología y Cirugía de Tórax (Drs. Caballero [Bogotá], Bolívar [Bucaramanga], Sanabria [Cali], Osorio [Barranquilla], and Orduz [Medellín]), Clínica Reina Sofía (Dr. Caballero), Bogotá; and Fundación Neumológica Colombiana (Drs. Torres-Duque, Jaramillo, and Maldonado, and Ms. Guevara), Bogotá, Colombia.

Correspondence to: Andrés Caballero, MD, Asociación Colombiana de Neumología y Cirugía de Tórax, Clínica Reina Sofía, Bogotá, Colombia; e-mail: ascaballero@colsanitas.com



Chest. 2008;133(2):343-349. doi:10.1378/chest.07-1361
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Background: The prevalence of COPD in Colombia is unknown. This study aimed to investigate COPD prevalence in five Colombian cities and measure the association between COPD and altitude.

Methods: A cross-sectional design and a random, multistage, cluster-sampling strategy were used to provide representative samples of adults aged ≥ 40 years. Each participant was interviewed (validated Spanish version of the Ferris Respiratory Questionnaire) and performed spirometry before and after 200 μg of inhaled salbutamol, using a portable spirometer according to American Thoracic Society recommendations. COPD definitions were as follows: (1) spirometric: fixed ratio (primary definition): FEV1/FVC < 70% after bronchodilator; (2) medical: a diagnosis of chronic bronchitis, emphysema, or COPD made by a physician; (3) clinical: cough and phlegm ≥ 3 months every year during ≥ 2 consecutive years (chronic bronchitis). Analysis was performed using statistical software.

Results: A total of 5,539 subjects were included. The overall COPD prevalence using the primary definition (spirometric) was 8.9%, ranging from 6.2% in Barranquilla to 13.5% in Medellín. The prevalence measured by the spirometric definition was higher than medical (2.8%) and clinical (3.2%) definitions. After the logistic regression analysis, the factors related with COPD were age ≥ 60 years, male gender, history of tuberculosis, smoking, wood smoke exposure ≥ 10 years, and very low education level. There was a nonsignificant tendency toward larger prevalence with higher altitude.

Conclusion: COPD is an important health burden in Colombia. Additional studies are needed to establish the real influence of altitude on COPD prevalence.

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