Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
Correspondence to: Kjell Toren, MD, Department of Occupational and Environmental Medicine, PO 414, Sahlgrenska University Hospital, Göteborg, Sweden; e-mail: Kjell.Toren@amm.gu.se
We are grateful for the comments by Dr. Olivieri and colleagues regarding one of our recent publications in CHEST (November 2006).1 Their message is that reference values for exhaled nitric oxide should be based on gender. However, we cannot find any support for that opinion in the data from our general population studies.1–2
One of the key messages in our first article was that gender was not related to exhaled nitric oxide when other factors were taken into account.1These results were based on multiple regression modeling, a technique that usually is applied when there are a lot of factors influencing the outcome. The results of our univariate analyses showed an association between gender and exhaled nitric oxide; however, those results are of limited value because they may be biased by other factors, such as height, that influence exhaled nitric oxide levels. We have extended our analyses and recently published reference values of exhaled nitric oxide among lifelong never-smokers excluding all subjects with asthma and asthma symptoms,2 and found that exhaled nitric oxide was not related to gender in that sample.
The authors have no conflicts of interest to disclose.
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