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The Tako-Tsubo Syndrome : An Underappreciated, Novel Disease Entity

Norbert Frey, MD; Hugo A. Katus, MD; Evangelos Giannitsis, MD
Author and Funding Information

Affiliations: Heidelberg, Germany ,  Dr. Frey is assistant professor, Dr. Katus is professor and department head, and Dr. Giannitsis is assistant professor, Department of Cardiology, Angiology, and Pneumatology, University of Heidelberg.

Correspondence to: Evangelos Giannitsis, MD, Assistant Professor of Medicine, Department of Cardiology, Angiology and Pneumatology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; e-mail: evangelos_giannitsis@med.uni-heidelberg.de



Chest. 2007;132(3):743-744. doi:10.1378/chest.07-1070
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The tako-tsubo syndrome is characterized by transient left ventricular dysfunction in the absence of obstructive coronary disease, typically precipitated by severe emotional or physical stress. The term tako-tsubo has been coined by the characteristic similarity of left ventricular appearance on angiography to a Japanese octopus trap. Frequently associated with ECG changes and elevated cardiac biomarkers, its presentation can mimic that of acute myocardial infarction. Tako-tsubo cardiomyopathy has first been described in Japanese patients in the early 1990s.1 Only recently, this syndrome has also been widely recognized in Western countries23; however, most of the current literature consists of case reports, and very few larger patient series have been published to date.

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