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Selected Reports |

Pulmonary Toxicity Associated With Erlotinib*

Vincent Liu, MD; Dorothy A. White, MD, FCCP; Maureen F. Zakowski, MD; William Travis, MD, FCCP; Mark G. Kris, MD, FCCP; Michelle S. Ginsberg, MD; Vincent A. Miller, MD; Christopher G. Azzoli, MD
Author and Funding Information

*From the Thoracic Oncology Service (Drs. Liu, Kris, Miller, and Azzoli), Division of Solid Tumor Oncology, Department of Medicine, the Pulmonary Service (Dr. White), Division of General Medicine, Department of Medicine, and the Departments of Pathology (Drs. Zakowski and Travis) and Radiology (Dr. Ginsberg), Memorial Sloan-Kettering Cancer Center, New York, NY.

Correspondence to: Vincent Liu, MD, 300 Pasteur Dr, H3143, Stanford, CA 94305; e-mail: vinliu@stanford.edu



Chest. 2007;132(3):1042-1044. doi:10.1378/chest.07-0050
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Interstitial lung disease (ILD) related to therapy with the drug gefitinib has been well reported. The adverse pulmonary effects of erlotinib are less well known. We report a case of fatal pulmonary toxicity in a patient with advanced non-small cell lung cancer who received erlotinib. He had been found to have pathologic findings of usual interstitial pneumonia (UIP) on the resected lung cancer specimen prior to receiving erlotinib. This case and other published evidence should alert physicians to the possibility of fatal erlotinib-induced ILD. Similar to reports in patients receiving gefitinib, those with pathologic findings of UIP on resected lung specimens or known pulmonary fibrosis may be at particular risk for erlotinib pulmonary toxicity.

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