0
Original Research: VENOUS THROMBOEMBOLISM |

Risk Factors for Venous Thromboembolism After Lung Transplantation*

Hilary A. Yegen, MD; David J. Lederer, MD; R. Graham Barr, MD, DrPh; Jessie S. Wilt, MD; Yixin Fang, PhD; Emilia Bagiella, PhD; Frank D’Ovidio, MD; Jeffrey M. Okun, BA; Joshua R. Sonett, MD; Selim M. Arcasoy, MD, FCCP; Steven M. Kawut, MD, MS, FCCP
Author and Funding Information

*From the Departments of Medicine (Drs. Yegen, Lederer, Barr, Wilt, Arcasoy, and Kawut, and Mr. Okun) and Surgery (Drs. D’Ovidio and Sonett), College of Physicians and Surgeons, the Department of Statistics (Dr. Fang), Graduate School of Arts and Sciences, and the Department of Biostatistics (Dr. Bagiella), Mailman School of Public Health, Columbia University, New York, NY.

Correspondence to: Steven M. Kawut, MD, MS, FCCP, Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, 622 W 168th St, PH 8, Room 101, New York, NY 10032; e-mail: sk2097@columbia.edu



Chest. 2007;132(2):547-553. doi:10.1378/chest.07-0035
Text Size: A A A
Published online

Background: The risk factors for venous thromboembolism (VTE) following lung transplantation are not well established. We aimed to estimate the incidence of VTE and to identify the risk factors for VTE after lung transplantation.

Methods: We performed a nested case-control study within the cohort of 121 patients who underwent lung transplantation at our center between August 2001 and July 2005. Control subjects were matched to case patients on the number of days from the time of transplant. Cox proportional hazards models were used to identify risk factors for VTE.

Results: Twenty-four patients had deep vein thromboses, and 6 patients had pulmonary emboli (3 patients had both) [22% of the cohort]. In multivariate models, older age (p < 0.05), diabetes mellitus (p = 0.03), and pneumonia (p = 0.02) were associated with a higher rate of VTE.

Conclusions: VTE is a frequent complication of lung transplantation. Older age, diabetes, and pneumonia increase the rate of VTE. Future studies of intensive VTE prophylaxis may be warranted.

Figures in this Article

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543