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Postgraduate Education Corner: PULMONARY AND CRITICAL CARE PEARLS |

Shortness of Breath and Hypoxemia After Chemotherapy With Carboplatin and Gemcitabine*

Sujatha Hariharan, MD; Carolyn H. Welsh, MD, FCCP
Author and Funding Information

*From the Department of Medicine (Dr. Hariharan), Division of Medical Oncology, University of Colorado Health Sciences Center, Aurora, CO; and the Department of Medicine (Dr. Welsh), Division of Pulmonary Sciences and Critical Care Medicine, Denver Veterans Affairs Medical Center, Denver, CO.

Correspondence to: Carolyn Welsh, MD, FCCP, Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, Denver Veterans Affairs Medical Center, Pulmonary Care 111A, 1055 Clermont St, Denver, CO 80220; e-mail: Carolyn.Welsh@med.va.gov



Chest. 2007;131(6):1978-1981. doi:10.1378/chest.06-1464
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Extract

A 68-year-old man with COPD and stage IV bladder cancer started therapy with gemcitabine (days 1 and 8) and carboplatin (day 1) every 3 weeks. After cycle 6, he was admitted to the hospital for neutropenic fever. Hypoxemia required supplemental oxygen therapy at 6 L/min via nasal cannula. Despite therapy with broad-spectrum antibiotics and the recovery of neutrophil counts, fever persisted. The patient complained of shortness of breath, cough with blood streaking, and green sputum.

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