Lung cancer is the second-most-common cancer diagnosis in men and women.1 It accounts for more deaths than prostate, breast, and colon cancer combined. Many risk factors for lung cancer have been identified. Smoking is the most prominent and modifiable risk factor. Still, 10 to 15% of lung cancers occur in those who are lifetime neversmokers (a person who has smoked < 100 cigarettes during lifetime) and 55 to 65% in those that have quit smoking. Many treatment modalities including chemotherapy, radiation, and surgery are now available for lung cancer therapy; however, the survival rates for the 60 to 70% of patients who present with advanced disease remain dismal.