0
Editorials |

Clinical Trial Registration Promotes Patient Protection and Benefit, Advances the Trust of Everyone, and Is Required

Richard S. Irwin, MD, FCCP
Author and Funding Information

Affiliations: Northbrook, IL ,  Dr. Irwin is Editor in Chief of CHEST.

Correspondence to: Richard S. Irwin, MD, FCCP, Editor in Chief, CHEST, 3300 Dundee Rd, Northbrook, IL 60062-2348; e-mail: rirwin@chestnet.org



Chest. 2007;131(3):639-641. doi:10.1378/chest.07-0088
Text Size: A A A
Published online

Extract

Because CHEST has signed on to adhere to the Uniform Requirements for Manuscripts Submitted to Biomedical Journals of the International Committee of Medical Journal Editors (ICMJE), we have endorsed the following principles: (1) investigators are required to register their clinical trials (other than phase 1 trials) in a public trials registry that is managed by a not-for-profit organization, free of charge for both registrants and users, and electronically searchable; (2) trial registration has been applied to trials that started recruiting on or after July 1, 2005, or, for trials that were ongoing by the July date, registration had to be completed before September 12, 2005; (3) a clinical trial has been defined as any research project that prospectively assigns human subjects to intervention or concurrent comparison or control groups to study the cause-and-effect relationship between a medical intervention (eg, drugs, devices, surgical procedures, behavior treatments) and a health outcome; and (4) clinical trials must be accurately and appropriately registered (eg, by filling out the minimum 20-item data set defined by the World Health Organization) before enrollment of the first patient to be considered for publication. Additionally, CHEST reserves the right to decline papers if, in its discretion, it deems the disclosure at the registry to be incomplete or inaccurate. Although these principles were first published in 20041 and they have been incorporated into the CHEST Instructions to Authors (www.chestjournal.org), we and others2 continue to receive manuscripts reporting results of clinical trials that have not been registered or that have been inaccurately registered.

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543