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Eosinophilic Pneumonia Due to Duloxetine*

Vidal J. Espeleta, MD; William H. Moore, MD; Philip B. Kane, MD; Daniel Baram, MD, FCCP
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*From the Division of Pulmonary/Critical Care Medicine (Drs. Espeleta and Baram), and the Departments of Radiology (Dr. Moore) and Pathology (Dr. Kane), Stony Brook University, Stony Brook, NY.

Correspondence to: Daniel Baram, MD, FCCP, Stony Brook University, Division of Pulmonary/Critical Care Medicine, Department of Medicine, T-17 040 HSC, Stony Brook, NY 11794-8172; e-mail: daniel.baram@stonybrook.edu



Chest. 2007;131(3):901-903. doi:10.1378/chest.06-1659
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A 32-year-old man presented with a 2-month history of worsening fever, chills, and cough despite therapy with oral antibiotics. Chest radiographs demonstrated migrating, peripheral upper lobe infiltrates. A CBC count demonstrated significant eosinophilia. At bronchoscopy, eosinophil-rich mucus was seen impacted throughout his bronchi. A transbronchial biopsy confirmed the diagnosis of eosinophilic pneumonia. Symptoms, eosinophilia, and radiographic abnormalities were reversed with cessation of duloxetine. This case report briefly reviews the diagnosis of drug-induced pulmonary infiltrates with eosinophilia (PIEs) and eosinophilic pneumonia. To our knowledge, this is the first reported case of PIEs due to duloxetine.

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