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Endotracheal Castleman Disease*: A Case Report

Truc T. Pham, MD; James H. Harrell, MD; Brian Herndier, MD, PhD; Eunhee S. Yi, MD
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*From Departments of Pathology (Drs. Pham, Herndier, and Yi) and Medicine (Dr. Harrell), School of Medicine, University of California, San Diego, La Jolla, CA.

Correspondence to: Eunhee S. Yi, MD, Division of Anatomic Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905; e-mail: yi.joanne@mayo.edu



Chest. 2007;131(2):590-592. doi:10.1378/chest.06-1346
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Castleman disease (CD) is an uncommon benign lymphoid hyperplasia with several clinical and morphologic variants associated with distinct outcomes. Pulmonary CD has been reported as a rare extranodal manifestation in the literature. However, CD presenting as an obstructive mass in the airway has not been documented. We report a case of localized hyaline-vascular CD presenting as an endotracheal lesion. The patient was a 50-year-old woman with Marfan syndrome. The lesion caused near-complete airway obstruction with respiratory insufficiency. The patient underwent laser resection, and the diagnosis of CD was supported by comprehensive studies including histopathologic, immunohistochemical, and molecular methods.

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