0
Original Research: INTERVENTIONAL PULMONOLOGY |

A Single Dose of Dexamethasone To Prevent Postbronchoscopy Fever in Children*: A Randomized Placebo-Controlled Trial

Elie Picard, MD; Shmuel Goldberg, MD; Dov Virgilis, MD; Shepard Schwartz, MD; David Raveh, MD; Eitan Kerem, MD
Author and Funding Information

*From the Department of Pediatrics and Pediatric Respiratory Medicine (Drs. Picard, Goldberg, Virgilis, and Schwartz), Infectious Disease Unit (Dr. Raveh), Shaare Zedek Medical Center, Jerusalem, affiliated to Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva; and Department of Pediatrics (Dr. Kerem), Hadassah Hebrew University Hospital, Mount Scopus, Jerusalem, Israel.

Correspondence to: Elie Picard, MD, Pediatric Pulmonology Unit, Shaare Zedek Medical Center, PO Box 3235, Jerusalem 91031, Israel; e-mail: Picard@szmc.org.il



Chest. 2007;131(1):201-205. doi:10.1378/chest.06-0337
Text Size: A A A
Published online

Study objective: To assess the effectiveness of one dose of dexamethasone (0.5 mg/kg; maximum, 10 mg) to prevent fever after bronchoscopy with BAL.

Design: Randomized, placebo-controlled study.

Patients: Immunocompetent nonfebrile children undergoing fiberoptic bronchoscopy with BAL.

Measurements and results: Sixty-nine children were included in the study. Thirty-eight children received saline solution, and 31 children received dexamethasone. The two groups were similar regarding the number of children < 2 years old, the percentage of abnormal bronchoscopic findings, the number of positive BAL culture findings, and the index of lipid-laden macrophages. Twenty-six children (68%) in the saline solution group (SG) had fever, compared to 3 children (9.6%) in the dexamethasone group (DG) [p < 0.001]. Fever after the procedure appeared later (12.3 ± 5.5 h) in the DG compared to 5.4 ± 2.7 h in the SG.

Conclusions: One dose of dexamethasone administered prior to performing bronchoscopy with BAL may prevent fever subsequent to the procedure. Further studies are necessary in order to determine the optimal dosing regimen for dexamethasone when used for this purpose.


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543